Cefdinir is associated with Lower Hospital Readmission Rates for Sepsis Patients at University Of Tennessee Medical Center based on Real World Evidence Study of Medicare Claims Data

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In Cefdinir, Sepsis

Background:

Sepsis is frequently associated with hospital readmission. Readmission is a hospital quality measure that reflects dimensions of quality of inpatient care and also impacts overall programs by payers such as CMS’s Star Rating Program, HRRP and Value-Based Purchasing. Cefdinir is a cephalosporin antibiotic that treats many types of bacterial infections. Studies have shown that appropriate and timely antibiotic treatment is one of the cornerstones of therapy to prevent deaths and life-threatening complications

Dexur’s analysis of Real-World Evidence based on Medicare Claims data showed that the use of Cefdinir within 7 days of hospitalization was associated with lower hospital readmission rates for Sepsis Patients at University Of Tennessee Medical Center in Knoxville, Tennessee. Reduction in readmission rates helps hospitals improve their outcomes for various cost and quality programs. Dexur is an approved entity to perform Medicare claims data analysis, which it uses to perform quality outcomes analysis. Dexur has published several papers with Harvard Medical School on quality outcomes related topics. Dexur’s analysis of Drugs and their impact on quality outcomes, such as readmissions and mortality, are used by Hospitals, IDNs, and ACOs to implement best practices and manage Real World Evidence based risk factors.

Methods:

We conducted a retrospective study using Dexur’s analysis of Real-World Evidence from Medicare Claims data, for hospitalizations at University Of Tennessee Medical Center between January 2017 to September 2019. Our methodology criteria was as follows:

1. Inclusion Criteria: Selected Medical Hospitalizations with Primary Diagnosis with Sepsis related codes (Listed in table below)

2. Stratified Selected population into cohorts

   1. Sepsis patients who dispensed Cefdinir within 7 Days of Hospitalization using Part D drugs claims database

   2. Sepsis patients who did not dispense Cefdinir within 7 Days of Hospitalization

3. 30 Day readmission rates were analyzed for both population cohorts

Results:

Overall, Cefdinir was associated with lower hospital readmission rates for all Primary ICD Diagnosis Codes examined at University Of Tennessee Medical Center. For patients whose primary ICD Diagnosis was “Sepsis, unspecified organism”(A419) and when Cefdinir was used within 7 days of hospitalization, the readmission rate was 19.4% compared to the cohort where Cefdinir was not used, whose readmission rate was 23.62%. The readmission odds ratio for these cohorts was 0.78. The use of Cefdinir was associated with a % lower readmission rate when used within 7 days of hospitalization. The full list of studied ICD codes, readmission rates, odds ratios, confidence intervals, and percentage reduction in readmission with Cefdinir at University Of Tennessee Medical Center is shown below.

Primary ICD Diagnosis Code	Primary ICD Diagnosis Code Description	Total Hospitalizations without Cefdinir	Readmission Without Cefdinir	Readmission Rate without Cefdinir	Total Hospitalizations with Cefdinir	Readmission with Cefdinir	Readmission Rate with Cefdinir	Readmission Odds Ratio	Reduction in Readmission with Cefdinir (%)	Confidence Interval (-)	Confidence Intervals (+)
A419	Sepsis, unspecified organism	2,688

Dexur also leveraged Medicare claims data to understand what percentage of patients hospitalized with Sepsis were not prescribed Cefdinir within 7 days of discharge.

ICD CODE	Hospital	Hospitalizations with Sepsis	% of Hospitalizations without Cefdinir
A419	University Of Tennessee Medical Center	2,701	99.52%
	Oroville Hospital	5,103	99.75%
	Methodist University Hospital	4,760	99.75%

Hospitalizations with Sepsis = Above Listed ICD Codes

If figures are shared with “At Least” - this implies that the drug utilization within 7 days post hospitalization is less than 11

Conclusions:

According to analysis of Real-World Evidence of Medicare Claims data, for hospitalizations between January 2017 to September 2019, the use of Cefdinir within 7 days of hospitalization can lead to substantial reductions in hospital readmission rates of Sepsis patients at University Of Tennessee Medical Center. This analysis shows that a significant number of Patients are not dispensed Cefdinir after Sepsis hospitalizations at University Of Tennessee Medical Center or major US Hospitals.

Cefdinir is associated with Lower Hospital Readmission Rates for Sepsis Patients at University Of Tennessee Medical Center based on Real World Evidence Study of Medicare Claims Data

Background:

Sepsis is frequently associated with hospital readmission. Readmission is a hospital quality measure that reflects dimensions of quality of inpatient care and also impacts overall programs by payers such as CMS’s Star Rating Program, HRRP and Value-Based Purchasing. Cefdinir is a cephalosporin antibiotic that treats many types of bacterial infections. Studies have shown that appropriate and timely antibiotic treatment is one of the cornerstones of therapy to prevent deaths and life-threatening complications

Dexur’s analysis of Real-World Evidence based on Medicare Claims data showed that the use of Cefdinir within 7 days of hospitalization was associated with lower hospital readmission rates for Sepsis Patients at University Of Tennessee Medical Center in Knoxville, Tennessee. Reduction in readmission rates helps hospitals improve their outcomes for various cost and quality programs. Dexur is an approved entity to perform Medicare claims data analysis, which it uses to perform quality outcomes analysis. Dexur has published several papers with Harvard Medical School on quality outcomes related topics. Dexur’s analysis of Drugs and their impact on quality outcomes, such as readmissions and mortality, are used by Hospitals, IDNs, and ACOs to implement best practices and manage Real World Evidence based risk factors.

Methods:

We conducted a retrospective study using Dexur’s analysis of Real-World Evidence from Medicare Claims data, for hospitalizations at University Of Tennessee Medical Center between January 2017 to September 2019. Our methodology criteria was as follows:

1. Inclusion Criteria: Selected Medical Hospitalizations with Primary Diagnosis with Sepsis related codes (Listed in table below)

2. Stratified Selected population into cohorts

   1. Sepsis patients who dispensed Cefdinir within 7 Days of Hospitalization using Part D drugs claims database

   2. Sepsis patients who did not dispense Cefdinir within 7 Days of Hospitalization

3. 30 Day readmission rates were analyzed for both population cohorts

Results:

Overall, Cefdinir was associated with lower hospital readmission rates for all Primary ICD Diagnosis Codes examined at University Of Tennessee Medical Center. For patients whose primary ICD Diagnosis was “Sepsis, unspecified organism”(A419) and when Cefdinir was used within 7 days of hospitalization, the readmission rate was 19.4% compared to the cohort where Cefdinir was not used, whose readmission rate was 23.62%. The readmission odds ratio for these cohorts was 0.78. The use of Cefdinir was associated with a % lower readmission rate when used within 7 days of hospitalization. The full list of studied ICD codes, readmission rates, odds ratios, confidence intervals, and percentage reduction in readmission with Cefdinir at University Of Tennessee Medical Center is shown below.

Primary ICD Diagnosis Code	Primary ICD Diagnosis Code Description	Total Hospitalizations without Cefdinir	Readmission Without Cefdinir	Readmission Rate without Cefdinir	Total Hospitalizations with Cefdinir	Readmission with Cefdinir	Readmission Rate with Cefdinir	Readmission Odds Ratio	Reduction in Readmission with Cefdinir (%)	Confidence Interval (-)	Confidence Intervals (+)
A419	Sepsis, unspecified organism	2,688

Dexur also leveraged Medicare claims data to understand what percentage of patients hospitalized with Sepsis were not prescribed Cefdinir within 7 days of discharge.

ICD CODE	Hospital	Hospitalizations with Sepsis	% of Hospitalizations without Cefdinir
A419	University Of Tennessee Medical Center	2,701	99.52%
	Oroville Hospital	5,103	99.75%
	Methodist University Hospital	4,760	99.75%

​Hospitalizations with Sepsis = Above Listed ICD Codes

If figures are shared with “At Least” - this implies that the drug utilization within 7 days post hospitalization is less than 11

Conclusions:

According to analysis of Real-World Evidence of Medicare Claims data, for hospitalizations between January 2017 to September 2019, the use of Cefdinir within 7 days of hospitalization can lead to substantial reductions in hospital readmission rates of Sepsis patients at University Of Tennessee Medical Center. This analysis shows that a significant number of Patients are not dispensed Cefdinir after Sepsis hospitalizations at University Of Tennessee Medical Center or major US Hospitals.